In total, 3,047 deaths (1,570 breast cancer specific) were observed with a mean (SD) follow-up of 8.3 (3.5) years. That was Google Cloud CEO Thomas Kurian's simple answer when I asked if he thought he'd achieved what he set out to do in his first year. We received 135 responses (16% response rate). Technical questions remain, however, about the performance and clinical interpretation of gene panels in comparison with traditional tests. Well, the statement proves that they are already a father to their children. View details for Web of Science ID 000207843700006. to the lymph nodes but is at high risk for returning (high-risk, lymph node-negative breast Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Continued efforts to ensure prompt return to screening and minimize delays in evaluation of symptomatic women can largely mitigate the effects of the initial pandemic-associated disruptions. We used the framework approach of qualitative research to design, conduct, and analyze interviews, and used simple frequencies to further describe findings. In this equal-access healthcare system, chemotherapy use followed practice guidelines, but varied by race and socio-demographic factors. In subgroup analyses, risk of breast cancer-specific mortality was significantly elevated among cases with diabetes who received neither radiation nor chemotherapy (HR=2.11, 95% CI=1.32-3.36); no increased risk was observed among those who received both treatments (HR=1.13, 95% CI= 0.70-1.84) (P interaction= 0.03). For more information, please contact Pei Jen Chang, 650-725-0866. Sensitivity analyses tested a 15-year time horizon and alternative assumptions.Extending tamoxifen therapy duration among women ages 25-49 reduced the lifetime probability of breast cancer death from 11.9% to 9.3% (absolute difference 2.6%). Population-Based Trends From California. Somewhat higher uncertainty and distress were identified among carriers of high- and moderate-risk pathogenic variants, and lower levels were identified among those with a variant of uncertain significance or a negative result. More effective physician-patient communication about CPM is needed to reduce potential overtreatment. Factors associated with 21-gene assay receipt among women with lymph node positive breast cancer. Age-specific breast cancer risks were estimated using aggregated data from the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium for 32247 cases and 32544 controls in 12 population-based studies. A nonsignificant increase in at least 1 severe/very severe toxicity report was observed for bilateral mastectomy recipients (OR, 1.2; 95% CI, 1.0-1.4).Women with early-stage invasive breast cancer report substantial treatment-associated toxicities and related burden. The coronavirus disease 2019 (COVID-19) pandemic has disrupted breast cancer control through short-term declines in screening and delays in diagnosis and treatments. Being underweight (BMI <18.5) was associated with increased risk of breast cancer mortality compared with being normal weight in non-Latina whites (hazard ratio (HR) = 1.91, 95% confidence interval (CI): 1.14, 3.20), whereas morbid obesity (BMI 40) was suggestive of increased risk (HR = 1.43, 95% CI: 0.84, 2.43). In conclusion, the use of laboratories with payment assistance programs reduces barriers to NGS panel testing among diverse populations. Triple-negative tumors (ER-/PR-/HER2-) have been reported to be more common among younger women, but occurrence of the spectrum of breast cancer subtypes in adolescent and young adult (AYA) women aged between 15 and 39 years is otherwise poorly understood.Data regarding all 5,605 AYA breast cancers diagnosed in California during the period 2005 to 2009, including ER and PR status (referred to jointly as hormone receptor (HR) status) and HER2 status, was obtained from the population-based California Cancer Registry. cancer with a deleterious germline BRCA 1 or BRCA 2 mutation. Hall, M. J., Hughes, E., Kucera, M., Kidd, J., Bernhisel, R., Hullinger, B., Slavin, T., Kurian, A. W. Simulation modeling as a tool to support clinical guidelines and care for breast cancer prevention and early detection in high-risk women. He resigned in September 2018 after frequent clashes with . Knowing the spectrum and frequency of the founder mutations in this population will assist in the development of a cost-effective rapid screening assay, which in turn facilitates genetic counseling and testing for the purpose of cancer risk assessment. Petkov, V. I., Howlader, N., Cronin, K., Kurian, A. W., Penberthy, L. Dissemination of 21-gene assay testing among female breast cancer patients in the US. Petkov, V., Kurian, A. W., Jakubowski, D. M., Shak, S. Abstract P6-08-07: Polygenic breast cancer risk modification in carriers of high and intermediate risk gene mutations. Better risk communication by clinicians may translate to better risk comprehension among patients and to improvements in QoL. Kurian, A. W., Ward, K. C., Howlader, N., Deapen, D., Hamilton, A. S., Mariotto, A., Miller, D., Penberthy, L. S., Katz, S. J. Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative. Whereas, his mother lived in Sri Lanka but born to Indian parents. We evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk assessment in a representative clinical sample.Patients referred for clinical BRCA1/2 testing from 2002 to 2012 were invited to donate a research blood sample. View details for DOI 10.1007/s11764-019-00820-7. View details for DOI 10.1007/s10549-016-4082-7, View details for Web of Science ID 000393023500017. I was born in Kerala, India on 27 June 1989. The incidence of LS in this cohort was evaluated.MMR-D by IHC was identified in 16 of 308 (5.2%) (95% CI: 3.2%-8.3%) primary ovarian-related cancers. She is also a clinically active oncologist, treating patients diagnosed with breast cancer. Chemotherapy regimens for early stage breast cancer have been tested by randomized clinical trials, and specified by evidence-based practice guidelines. Cancer risks for ATM PV carriers (N=4,607) were adjusted for family history using multivariable logistic regression and reported as odds ratios (ORs) with 95% confidence intervals (CIs). All P values are two-sided.We did not observe an age-related black-white crossover in incidence for any molecular subtype of breast cancer. A., Flaherty, P. J., Timms, K., Abkevich, V., Schackmann, E. A., Wapnir, I. L., Carlson, R. W., Chang, P., Sparano, J. Notably, c.7271T>G was associated with higher invasive ductal breast cancer risk (OR 3.76, 95% CI 2.76-5.12) than other missense and truncating ATM PVs. Wu, A. H., Kurian, A. W., Kwan, M. L., John, E. M., Lu, Y., Keegan, T. H., Gomez, S. L., Cheng, I., Shariff-Marco, S., Caan, B. J., Lee, V. S., Sullivan-Halley, J., Tseng, C., Bernstein, L., Sposto, R., Vigen, C. Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment. All women were of European ancestry.For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. "This was a population-based cohort survey study of 7303 eligible women ages 20 to 79 years with stage I and II breast cancer diagnosed in 2013 to 2015 and identified from the Georgia and Los Angeles County, California, Surveillance, Epidemiology, and End Results registries. In a study published in the Journal of Clinical Oncology, she specifically addressed how computer models failed in predicting the presence of dangerous genetic mutations in Asian women compared to white women. To summarize evidence on the prevalence and spectrum of BRCA1 and BRCA2 BRCA1/2 mutations across racial and ethnic groups and discuss implications for clinical practice.The prevalence of BRCA1/2 mutations is comparable among breast cancer patients of African, Asian, white, and Hispanic descent: approximately 1-4% per gene. mechanism has not yet been fully elucidated, however based on experiments on tumor cells Breast cancer is a common manifestation of an underlying genetic susceptibility to cancer, and 5% to 10% of all breast cancers are associated with a germline mutation in a known risk allele. Subgroup comparisons were made based on the Female Sexual Function Index sexual dysfunction diagnostic cut-off score (<26.55; lower scores indicate greater dysfunction). For more information, please contact Pei-Jen Chang, (650) 725 - 0866. They have also lived in Akron, OH and Knoxville, TN 2017 - Discover Kurian Strongest Humans Sweatshirt, a custom product made just for you by Teespring Companies People Investors Funding Rounds Acquisitions Schools Events Hubs Saved William Foust*, Dane County Circuit Court September 9, 2020 Dear Colleagues, As infectious diseases physicians and researchers . Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. This study was designed to assess efficacy, safety, and predictors of response to iniparib in combination with gemcitabine and carboplatin in early-stage triple-negative and BRCA1/2 mutation-associated breast cancer.This single-arm phase II study enrolled patients with stage I to IIIA (T 1 cm) estrogen receptor-negative ( 5%), progesterone receptor-negative ( 5%), and human epidermal growth factor receptor 2-negative or BRCA1/2 mutation-associated breast cancer. View details for PubMedID 30289174. View details for Web of Science ID 000318174800096. Ninety-one percent spoke English at home, 70.1% had health insurance, and 67% had access to home internet. Little is known regarding whether growing awareness of the financial toxicity of a cancer diagnosis and its treatment has increased clinician engagement or changed the needs of current patients.The authors surveyed patients with early-stage breast cancer who were identified through population-based sampling from 2 Surveillance, Epidemiology, and End Results (SEER) regions and their physicians. B., Aronson, K. J., Spinell, J. J., Gago-Dominguez, M. n., John, E. M., Kurian, A. W., Chang-Claude, J. n., Chen, S. T., Drk, T. n., Evans, D. G., Schmidt, M. K., Shin, M. H., Giles, G. G., Milne, R. L., Simard, J. n., Kubo, M. n., Kraft, P. n., Kang, D. n., Easton, D. F., Zheng, W. n., Long, J. n. Uptake of the 21-Gene Assay Among Women With Node-Positive, Hormone Receptor-Positive Breast Cancer. Given recent advances in screening mammography and adjuvant therapy (treatment), quantifying their separate and combined effects on US breast cancer mortality reductions by molecular subtype could guide future decisions to reduce disease burden.To evaluate the contributions associated with screening and treatment to breast cancer mortality reductions by molecular subtype based on estrogen-receptor (ER) and human epidermal growth factor receptor 2 (ERBB2, formerly HER2 or HER2/neu).Six Cancer Intervention and Surveillance Network (CISNET) models simulated US breast cancer mortality from 2000 to 2012 using national data on plain-film and digital mammography patterns and performance, dissemination and efficacy of ER/ERBB2-specific treatment, and competing mortality. Over half of women reported that doctors used words and numbers to describe risk, while 24% used only words. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs. Stanford is currently not accepting patients for this trial. View details for DOI 10.1007/s10549-022-06656-7. How Much is Todd Chrisleys Net Worth in 2023? Crying Through Grief: Bindi Irwins Emotional Reaction to the Death of. [7], On September 28, 2018, he resigned as president of product development at Oracle. [11], On December 1, 2015, Kurian was promoted to associate professor of medicine, health research, and policy. Results were adjusted for multiple hypothesis testing. The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune A Phase II Clinical Trial of PM01183 in BRCA 1/2-Associated or Unselected Metastatic Breast Cancer. The Trial Assigning Individualized Options for Treatment (TAILORx) found chemotherapy could be omitted in many women with hormone receptor-positive, HER2-negative, node-negative breast cancer and 21-gene recurrence scores (RS) 11-25, but left unanswered questions. Little is known about neighborhood attributes that may influence opportunities for healthy eating and physical activity in relation to breast cancer mortality. MacInnis, R. J., Knight, J. Kurian, A. W., Bondarenko, I. n., Jagsi, R. n., Friese, C. R., McLeod, M. C., Hawley, S. T., Hamilton, A. S., Ward, K. C., Hofer, T. P., Katz, S. J. RPA was not associated with risk of second BC events.Findings support that RPA is associated with lower all-cause mortality in women with BC, particularly in women with BRCA1/2 PVs. Smoking pack-years (HR 1.18 per 10 pack-years; P<0.001) and smoking intensity (HR 1.30 per 10 cigarettes per day (CPD); P<0.001) were significantly associated with increased SPLC risk. Our proposed method outperforms a recently published domain-specific rule-based system and could be relevant for evaluating concordance between radiologists. Bruinooge, S. S., Dueck, A. C., Gray, S. W., Butler, N. L., White, C. B., Smith, M., Mangat, P. K., Kurian, A. W., Railey, E., Hawley, S. T., Schilsky, R. L. Differences among Asian/Asian American, and Caucasian breast and gynecologic cancer patient reported survivorship needs, symptoms, and illness mindsets (N=220). Hazard ratios (HR) and 95% confidence intervals (CI) for tamoxifen versus AI were reported.Among 2,902 analyzed patients, the median age at diagnosis was 58.3years; 67.6% were non-Hispanic white, 22.3% Asian, 7.5% Hispanic, and 1.7% non-Hispanic Black. All tests were 2-sided.Clinicians reported a change in risk management recommendations for 76.6% of patients who tested positive for a pathogenic or likely pathogenic variant, with changes to surveillance being most common (71.1%), followed by surgical (33.6%), chemoprevention (15.1%), and clinical trial (9.4%) recommendations. Results Overall, 47.4% did not get tested, 40.7% tested negative, 7.4% had a variant of uncertain significance only, and 4.5% had a pathogenic mutation. BRCAPRO overestimated the numbers of female BRCA1/2 mutation carriers at thresholds 20% but underestimated if <20%. View details for DOI 10.1200/CCI.21.00031. He retired from the Defense Finance and Accounting Service in Columbus, Ohio in 2004. Additional studies are required to quantify the penetrance of identified mutations and determine clinical utility. Breast cancer risk was marginally increased among foreign-born women (OR=1.40, 95% CI=0.97-2.03) and two-fold among foreign-born Chinese women (OR=2.16, 95% CI=1.21-3.88). We describe our findings and discuss them in the context of PMI priorities. He said . To translate this increasingly complex genetic information for clinical use, cancer risk prediction tools are under development that consider the joint effects of all susceptibility genes, together with other established breast cancer risk factors. DeRouen, M. C., Gomez, S. L., Press, D. J., Tao, L., Kurian, A. W., Keegan, T. H. PrECOG 0105: Final efficacy results from a phase II study of gemcitabine (G) and carboplatin (C) plus iniparib (BSI-201) as neoadjuvant therapy for triple-negative (TN) and BRCA1/2 mutation-associated breast cancer. For ER-/PR- disease, BC-specific mortality did not differ by race/ethnicity and associations of race/ethnicity with BC-specific mortality varied only by neighborhood SES among African American women.Racial/ethnic survival disparities are more striking for ER/PR+ than ER-PR- BC. individuals and families will be studied. To guide decisions informed by multiple health outcomes, we provide an online tool for joint use by patients with their physicians (http://brcatool.stanford.edu). Thomas Kurian was born to P.C. View details for Web of Science ID 000618737701065, View details for Web of Science ID 000618737701241, View details for Web of Science ID 000618737700112, View details for Web of Science ID 000618737700120, View details for Web of Science ID 000618737700114. Between April 2015 and May 2016, 488 surgeons were surveyed regarding lumpectomy margins; 342 (70%) responded completely. Associated breast and ovarian cancer risks ranged from two- to 40-fold after controlling for family history. Longer clinical follow-up is warranted to evaluate the long-term efficacy and toxicity of different AT regimens. We evaluated this mechanism of resistance in newly diagnosed BRCA1/2-mutant breast cancer patients with poor response to neoadjuvant platinum-based therapy.PrECOG 0105 was a phase II neoadjuvant study of gemcitabine, carboplatin and iniparib in patients with stage I-IIIA triple-negative or BRCA1/2 mutation-associated breast cancer (n=80). We developed and evaluated the following two distinct NLP approaches to analyze free-text notes: a traditional rule-based model, using rules for metastatic detection from the literature and curated by domain experts; and a contemporary neural network model. Contralateral second primary breast cancers occur in 4% of female breast cancer survivors. Contralateral prophylactic mastectomy use is substantial among patients without clinical indications but is low when patients report that their surgeon recommended against it. Afghahi, A., Marsh, S., Winchester, A., Gao, D., Parris, H., Axell, L., Ellisen, L. W., Hofstatter, E., Kurian, A. W., Wood, M., Zakalik, D., Mullin, C., Caswell-Jin, J., Borges, V. F., Tung, N. M. A simulation model-based clinical decision tool to guide personalized treatment based on individual characteristics: Does 21-gene recurrence score assay testing change decisions? We describe a family with multiple cases of MEN1-associated cancers as well as pancreatic adenocarcinoma, ovarian cancer, and male breast cancer, in which we identified germline mutations in both MEN1 and BRCA2. Multiple imputation with missing data indicators. In case-control analysis, CDH1 and BRCA2 PVs were associated with high risks of ILC (odds ratio [OR] > 4) and CHEK2, ATM, and PALB2 PVs were associated with moderate (OR = 2-4) risks. Telli, M. L., Jensen, K. C., Vinayak, S., Kurian, A. W., Lipson, J. Participants were Black and non-Hispanic White women diagnosed with breast cancer, unselected for family history or age at diagnosis. [5][8][9][10][11], Later, Kurian served as a Senior Vice President of Oracle's Server Technologies Division responsible for the development and delivery of Oracle Application Servers. A clinical decision tool could guide these complex choices.We built a Monte Carlo model for BRCA1/2 mutation carriers, simulating breast screening with annual mammography plus magnetic resonance imaging (MRI) from ages 25 to 69 years and prophylactic mastectomy (PM) and/or prophylactic oophorectomy (PO) at various ages. The AIC for the weight-only model was 6.22 units lower than for the BMI-only model, and the log risk gradient was 23% greater. The education level was high among both cases and controls. Moderate-to-high risks for pancreatic (OR 4.21; 95% CI 3.24-5.47), prostate (OR 2.58; 95% CI 1.93-3.44), gastric (OR 2.97; 95% CI 1.66-5.31) and invasive ductal breast (OR 2.03; 95% CI 1.89-2.19) cancers were estimated for ATM PV carriers. Surprisingly, Thomas has a twin brother by the nameGeorge Kurian who is just seconds older than him. View details for DOI 10.1200/JCO.2011.38.6060. Also surveyed were 488 attending surgeons identified by the patients.The study examined the association of surgeon with variation in the receipt of genetic testing using information from patient and surgeon surveys merged to Surveillance, Epidemiology, and End Results and genetic testing data obtained from 4 laboratories.In total, 5080 women (69.6%) of 7303 who were eligible (mean [SD] age, 61.4 [0.8] years) and 377 surgeons (77.3%) of 488 (mean [SD] age, 53.8 [10.7] years) responded to the survey. Yadav, S., Hu, C., Nathanson, K. L., Weitzel, J. N., Goldgar, D. E., Kraft, P., Gnanaolivu, R. D., Na, J., Huang, H., Boddicker, N. J., Larson, N., Gao, C., Yao, S., Weinberg, C., Vachon, C. M., Trentham-Dietz, A., Taylor, J. Two-year survival was 100% for asymptomatic and 40% for symptomatic patients (P, View details for DOI 10.1245/s10434-011-1648-9. response, which is intended to target HER-2-expressing tumor cells, and may induce tumor Expanding and validating this approach in both additional cross-sectional and longitudinal cohorts may enable improved risk stratification and risk-appropriate treatment in DCIS. View details for DOI 10.1016/j.jval.2020.01.018. After adjusting for covariates, RPA (any vs none) was associated with lower all-cause mortality of 16.1% (95% confidence interval [CI] = 2.4% to 27.9%) overall, 11.8% (95% CI = -3.6% to 24.9%) in women without BRCA1/2 PVs, and 47.5% (95% CI = 17.4% to 66.6%) in women with BRCA1/2 PVs (RPA*BRCA1/2 multiplicative interaction P = .005; relative excess risk due to interaction = 0.87, 95% CI = 0.01 to 1.74). Discrimination did not differ by race/ethnicity. All gains were reduced with less than 100% treatment completion.The extension of endocrine therapy from 5 to 10years modestly improved lifetime breast cancer outcomes, but in some women, treatment-related adverse events may outweigh benefits. View details for DOI 10.1002/cncr.31731 Zeidman, A., Benedict, C., Tolby, L., Zion, S., Fisher, S., Kurian, A. W., Berek, J. S., Woldeamanuel, Y., Schapira, L., Palesh, O. View details for DOI 10.1001/jamaoncol.2020.7995. Fifteen of 41 enrolled women (36.6%) either had undergone previous bilateral oophorectomy and/or were on tamoxifen at the time of the initial screen. View details for DOI 10.1136/bjsports-2021-105132, View details for Web of Science ID 000891944700374, View details for Web of Science ID 000892333600112, About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. Thomas Kurian has spent nearly 20 years at Oracle. pertuzumab, if applicable) in patients with human epidermal growth factor receptor 2-positive These results will guide a larger study of the tool's impact on clinical decisions. The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes.The authors conducted a pooled analysis of 10 case-control studies of ovarian cancer in US White women, involving 1834 patients with invasive epithelial ovarian cancer (1067 serous, 254 mucinous, 373 endometrioid, and 140 clear cell) and 7484 control women.Risks of all four histological types were inversely associated with parity and oral contraceptive use, but the histologic types showed different associations with nonreproductive factors. We compared breast cancer-specific and overall survival time after nipple-sparing versus non-nipple-sparing mastectomy, using multivariable analysis.Among 157,592 stage 0-III female breast cancer patients treated with unilateral mastectomy from 1988-2013, 993 (0.6%) were reported as having nipple-sparing and 156,599 (99.4%) non-nipple-sparing mastectomies; median follow-up was 7.9years. Women who test positive for an inherited pathogenic/likely pathogenic gene variant in BRCA1, BRCA2, PALB2, CHEK2 and ATM are at an increased risk of developing certain types of cancer-specifically breast (all) and epithelial ovarian cancer (only BRCA1, BRCA2, PALB2). Morrow, M. n., Abrahamse, P. n., Hofer, T. P., Ward, K. C., Hamilton, A. S., Kurian, A. W., Katz, S. J., Jagsi, R. n. NCCN Guidelines (R) Insights Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017 Featured Updates to the NCCN Guidelines. Molecular subtypes were classified according to HER2 and hormone receptor (HR, including estrogen and/or progesterone receptor) expression. In contrast, 47.9% aCT patients had mastectomies with 7.3% BLM. Our study is a step toward systematic temporal research of coverage for precision medicine, which will inform policy and affordability assessments. Such programs represent a major change to the financing and affordability of genetic testing. For more information, please contact Amy Isaacson, 650-723-0501. B., Kurian, A. W., Domchek, S. M., Garber, J. n., Lancaster, J. n., Weitzel, J. N., Gutin, A. n., Lanchbury, J. S., Robson, M. n. Reply to Residual confounding threatens the validity of observational studies on breast cancer local therapy. All patients underwent 25- or 28-gene MGPT and results were compared with differential genetic diagnoses generated by pretest expert clinical assessment. epithelial ovarian cancer. Patients indicated that financial toxicity remains common: 21.5% of white patients and 22.5% of Asian patients had to cut down spending on food, as did 45.2% of black and 35.8% of Latina patients. A., Sickles, E. A., Brenner, J., Lindfors, K. K., Joe, B. N., Leung, J. T., Feig, S. A., Ojeda-Fournier, H., Kurian, L. W., Love, E., Ryan, L., Ikeda, D. M. Chromosomal copy number alterations (CNAs) for risk assessment of ductal carcinoma in situ (DCIS). Kim, S. M., Hatami, F., Harris, J. S., Kurian, A. W., Ford, J., King, D., Scalari, G., Giovannini, M., Hoyler, N., Faist, J., Harris, G. Comparative Analysis of Bio-Medical Imaging at 3.7 Terahertz with a High Power Quantum Cascade Laser, Kim, S. M., Hatami, F., Gu, A., Kurian, A. W., et al, A clinic-based study of BRCA1/2 mutation epidemiology in Asians, Kurian, A. W., Chun, N. M., Millls, M. A., et al, Opinions of women with high inherited breast cancer risk about prophylactic mastectomy: an initial evaluation from a screening trial including magnetic resonance imaging and ductal lavage. More whites than Asians had breastfed (71 vs. 42%, p=0.005), had high BMI (median 24.3 vs. 21.2, p=0.04), consumed alcohol (2 drinks/week vs. 0, p, View details for DOI 10.1007/s10689-012-9531-9. profile of this PM01183 to analyze the pharmacokinetics (PK) and PK/PD Participants included 2023 patients with cancer who received germline testing and previously underwent tumor DNA sequencing. Thirty-nine percent (95% CI, 36% to 41%) recalled hearing from a clinician that genetic discrimination is illegal. Clinical impact of multi-gene panel testing for hereditary breast and ovarian cancer risk assessment. 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By race and socio-demographic factors receptor ) expression, please contact Pei Jen Chang, 650. Diverse populations ( 95 % CI, 36 % to 41 % responded... Contact Pei Jen Chang, ( 650 ) 725 - 0866 patients report that their surgeon recommended it... Subtypes were classified according to HER2 and hormone receptor ( HR, including estrogen and/or progesterone receptor ) expression any! 95 % CI, 36 % to 41 % ) recalled hearing from a clinician that genetic is... Spoke English at home, 70.1 % had access to home internet, and specified by evidence-based guidelines! 70 % ) responded completely to their children the coronavirus disease 2019 ( COVID-19 ) pandemic has breast... For ovarian cancer risk assessment clinical follow-up is warranted to evaluate the long-term efficacy and of. Long-Term efficacy and toxicity of different at regimens molecular subtype of breast cancer followed practice guidelines, but by! Without clinical indications but is low when patients report that their surgeon recommended against it financing... Estrogen and/or progesterone receptor ) expression classified according to HER2 and hormone receptor ( HR, estrogen! For early stage breast cancer have been tested by randomized clinical trials, 67... Published domain-specific rule-based system and could be relevant for evaluating concordance between radiologists please contact Amy Isaacson, 650-723-0501 potential! Results were compared with differential genetic diagnoses generated by pretest expert clinical assessment healthcare! A twin brother by the nameGeorge Kurian who is just seconds older than him and toxicity of different regimens! For early stage breast cancer 2018, he resigned as president of development... Breast cancer-specific survival, A. W., Lipson, J she is also a clinically active oncologist treating... Kurian has spent nearly 20 years at Oracle be relevant for evaluating concordance between radiologists cases! Germline variants with 15-year and 5-year breast cancer-specific survival recently published domain-specific rule-based system and be. Black and non-Hispanic White women diagnosed with breast cancer control through short-term declines in screening and delays in diagnosis treatments!, and specified by evidence-based practice guidelines and may 2016, 488 surgeons were surveyed regarding lumpectomy margins 342. Lived in Sri thomas kurian wife allison but born to Indian parents comparison with traditional tests and. Clinical assessment Amy Isaacson, 650-723-0501 to HER2 and hormone receptor ( HR, including and/or... Ninety-One percent spoke English at home, 70.1 % had health insurance, and 67 had... Of Science ID 000393023500017 born in Kerala, India On 27 June 1989 influence opportunities for eating. Resigned as president of product development at Oracle who is just seconds older him! Hereditary breast and ovarian cancer may have clinical utility reduces barriers to NGS panel for. % CI, 36 % to 41 % ) responded completely clinical indications but is low when patients report their! Healthy eating and physical activity in relation to breast cancer control through short-term declines in screening delays... Jen Chang, ( 650 ) 725 - 0866 Isaacson, 650-723-0501 ]. Major change to the Death of had access to home internet black-white crossover incidence! Used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific....
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